180 Life Sciences Rebrands as ETHZilla with $425M Ethereum Play

- Nasdaq-listed biotech firm 180 Life Sciences rebrands as ETHZilla Corporation and pivots to an Ethereum-focused treasury strategy. - A $425 million PIPE deal supports the shift, allowing the company to acquire Ether (ETH) and integrate decentralized finance (DeFi) practices. On July 29, 2025, Nasdaq-listed biotech company 180 Life Sciences (NASDAQ: ATNF) announced a strategic pivot, rebranding as ETHZilla Corporation to adopt an Ethereum-focused treasury model. ETHZilla will integrate decentralized finance (DeFi) principles and align with emerging cryptocurrency trends to distinguish itself in the digital finance space. A $425 million private investment in public equity (PIPE) deal supports this initiative by funding the acquisition of Ether (ETH). The deal, which involves over 60 institutional and crypto-native investors, including Electric Capital, Polychain Capital, and GSR, is expected to close around August 1, according to reports from PR Newswire, Investing.com, and Seeking Alpha on July 29. The rebranding addresses the company's ongoing financial hurdles, as 180 Life Sciences has faced underperformance and a declining stock value since its 2020 initial public offering. As of July 29, its market capitalization stood at $17.57 million. The firm’s previous attempts to pivot into the blockchain-based gaming sector failed to gain significant traction; therefore, the shift to an Ethereum treasury repositions its business strategy and allows it to explore opportunities within the DeFi ecosystem. ETHZilla Corporation has appointed Electric Capital as its external asset manager to oversee the company's on-chain yield strategy, which includes staking, lending, and liquidity provisioning. To enhance Ethereum yield generation and contribute to the DeFi domain, ETHZilla also plans to establish a "DeFi Council" composed of prominent leaders in the space. This strategic move reflects a growing trend where businesses use cryptocurrency-based treasury strategies to access new forms of digital liquidity and financial innovation. While the management team and most directors will remain in place, McAndrew Rudisill is expected to take on the role of chairman of the board as part of the reorganization. Meanwhile, according to CoinMarketCap on July 29, Ethereum (ETH) was trading at $3,772.26 at 19:10 UTC, a price that reflected a 0.65% decrease in its 24-hour trading volume.